Effingham is a city in Effingham County, Illinois, United States. The population was 12,384 at the 2000 census. It is the county seat of Effingham County. The city bills itself as "The Crossroads of Opportunity" & "Crossroads of many state police" because of its location at the intersection of two major Interstate highways: I-57 running from Chicago to Miner, Missouri, and I-70 running from Utah to Maryland. Thus, Effingham has a broad range of restaurants, lodging, and shopping facilities. Effingham is also located on U.S. Highway 40, the historic National Road.