Clarksville is a town in Clark County, Indiana, along the Ohio River as a part of the Louisville Metropolitan area. The population was 21,400 at the 2000 United States Census. The town, once a home site to George Rogers Clark, was founded in 1783 and is the oldest American town in the Northwest Territory. The town is home to the Colgate clock, one of the largest clocks in the world and the Falls of the Ohio State Park, a large fossil bed.